What this category covers
Analytical instruments determine what a sample contains and in what quantity. They are laboratory instruments by definition, because a sample is taken, prepared and measured under controlled conditions - which is what distinguishes them from the online analysers that work directly on a process stream, and the two are specified in completely different conversations.
Because these systems are normally bought against a documented method, the specification starts with three things and works outwards: the analyte, meaning the substance to be measured; the matrix, meaning everything else in the sample; and the detection limit the result has to reach. Only once those are fixed does the question of which technique and which configuration follow.
That order matters because the same substance can be measured by several techniques with very different running costs, and choosing by technique rather than by requirement is how a laboratory ends up with an instrument it cannot use for the method it has to follow. The supporting environment - gases, vacuum, cooling, consumables and reference standards - is part of the decision rather than an afterthought.
Product types in analytical instruments
| Product type | How it measures | Usually specified for |
| UV-Vis spectrophotometer | Absorption of light at defined wavelengths, converted to concentration through a calibration curve | Quantitative measurement of species that absorb in the ultraviolet or visible range, and routine methods built on colour-forming reactions |
| FTIR spectrometer | Absorption of infrared energy by molecular bonds, compared against reference spectra | Identification of materials and functional groups, including solids and formulations where a quantitative method is not required |
| Gas chromatograph | Components are separated in a carrier gas stream and detected as they elute | Volatile and semi-volatile mixtures, residual solvents, and purity checks where a separation is required before identification |
| Liquid chromatograph | Components are separated in a liquid mobile phase across a stationary phase | Non-volatile, thermally labile and ionic compounds that would not survive a gas chromatographic method |
| Mass spectrometer | Ions are separated by mass-to-charge ratio and detected, giving high specificity | Confirmation and identification where a low detection limit and an unambiguous answer are both required |
| Atomic absorption spectrometer | Ground-state atoms absorb light at element-specific wavelengths | Metal concentrations in water, soils, alloys and biological samples, where one element is determined at a time |
| TOC analyser | Organic carbon is oxidised and the resulting carbon dioxide is measured | Water and wastewater work where organic loading is the reported figure, and where a regulatory limit applies |
| Particle size analyser | Laser diffraction or image analysis derives a size distribution from the sample | Powders, suspensions and emulsions, where the distribution rather than a single value is the result |
Colorimeters, elemental analysers and the accessories that support these systems are listed under this category as well.
How to choose a analytical instrument
There is rarely a single correct instrument for a duty, but there is always a
shortlist that can be justified and a set of answers that eliminates the rest. These
are the questions that decide it.
- The analyte and the matrix together, because the matrix often decides the technique more than the substance does - a clean water sample and a digested solid are different problems with the same target.
- The detection limit and the reporting threshold, including any regulatory level the result has to be compared against rather than merely detected at.
- The method or standard the laboratory follows, since an accredited procedure usually names the technique and the acceptance criteria.
- Throughput: number of samples, preparation time and whether the laboratory works in batches or continuously, which decides whether automation is worth having.
- The sample preparation route, because extraction, digestion and dilution frequently take longer than the measurement and set the real capacity of the laboratory.
- Consumables and their supply: columns, lamps, gases, solvents, standards and reference materials, all of which have a running cost and a shelf life.
- The support environment required: bench space, vacuum, cooling, gas supply, ventilation and power, which is frequently the constraint on which instrument can be installed at all.
- Data handling: whether results have to be reported in a defined format, held in a laboratory system, or audited against the raw data.
- Service and calibration support, including access to reference standards and to a service arrangement that can respond within the laboratory downtime tolerance.
Working through the selection in order
- State the analyte, the matrix and the concentration range, and confirm what the result is compared against.
- Identify the method or standard the laboratory has to follow, since it may fix the technique before anything else is considered.
- Establish the detection limit and the acceptance criteria the result has to satisfy.
- Choose the technique from those three answers, using the comparison above, rather than from familiarity with one system.
- Work out the sample preparation route and check that it can be carried out with the equipment and the staff available.
- Size the system for the throughput required, including whether an autosampler or an automated preparation step is justified.
- Confirm the installation: gases, vacuum, cooling, ventilation, power and bench space, which frequently decide feasibility.
- Decide the consumables, standards and service arrangement that have to be in place for the system to run from day one.
Comparing the technologies
| Technology | Best suited to | Limits | Typical question |
| UV-Vis molecular absorption | Quantitative methods built on an absorbing species or a colour-forming reaction | Needs a chromophore, is exposed to matrix interference, and depends on careful cuvette handling and blanking | How much of a known substance is present |
| FTIR spectroscopy | Identifying what a material is, including solids and mixtures | Water and some matrices interfere, and interpreting a complex mixture depends on the reference libraries available | What is this material |
| Gas chromatography | Volatile and semi-volatile mixtures that have to be separated before they are measured | The sample has to be volatile and thermally stable, and column and detector selection decide what can be resolved | Which components are present, and in what proportion |
| Liquid chromatography | Non-volatile, labile and ionic compounds, including large molecules | Solvent consumption and method development time; the mobile phase becomes a running cost and a disposal question | What is the composition of a liquid mixture |
| Atomic absorption | Metal concentrations across a wide range of matrices | The classical arrangement determines one element at a time, and some elements need a different atomisation approach | How much of this metal is present |
| Mass spectrometry | Identification and confirmation at low concentration, alone or as a detector for a separation technique | Needs vacuum, a controlled environment, consumables and skilled interpretation; it is rarely a stand-alone first purchase | Exactly what is present, at very low concentration |
Parameters to confirm before ordering
What is left after the technology is chosen is a list of values that only the
installation can supply. These are the ones that change the model, the price or the
lead time:
- The analyte or analytes, and the matrix the sample comes in.
- The concentration range and the detection limit the method requires.
- The method or standard the laboratory follows, or the acceptance criteria the result is reported against.
- The sample form and the preparation route, including any digestion, extraction or dilution step.
- Throughput: samples per day or per batch, and the time available for preparation.
- The installation available: bench space, power, gases, vacuum, cooling and ventilation.
- Data requirements: result format, software, storage and whether raw data has to be retained.
- Consumables and reference standards required with the initial order.
- Calibration and service expectations, including the interval and the response time the laboratory needs.
- Whether the laboratory operates under a quality system, and what documentation has to accompany the system.
Figures are quoted, not assumed
Specifications vary by model and application, so no performance figure is stated on
this page. Where a parameter has not been documented for a particular model, the
product page says so rather than filling the gap with a plausible number. Send the
values above and we will return the ones the selected model actually holds.
Where these instruments are used