Analysis & Monitoring

Analytical Instruments for Composition & Structure

Spectrophotometers, chromatography systems, mass spectrometers and elemental analysers for composition and structure.

What this category covers

Analytical instruments determine what a sample contains and in what quantity. They are laboratory instruments by definition, because a sample is taken, prepared and measured under controlled conditions - which is what distinguishes them from the online analysers that work directly on a process stream, and the two are specified in completely different conversations.

Because these systems are normally bought against a documented method, the specification starts with three things and works outwards: the analyte, meaning the substance to be measured; the matrix, meaning everything else in the sample; and the detection limit the result has to reach. Only once those are fixed does the question of which technique and which configuration follow.

That order matters because the same substance can be measured by several techniques with very different running costs, and choosing by technique rather than by requirement is how a laboratory ends up with an instrument it cannot use for the method it has to follow. The supporting environment - gases, vacuum, cooling, consumables and reference standards - is part of the decision rather than an afterthought.

Product types in analytical instruments

Product typeHow it measuresUsually specified for
UV-Vis spectrophotometer Absorption of light at defined wavelengths, converted to concentration through a calibration curveQuantitative measurement of species that absorb in the ultraviolet or visible range, and routine methods built on colour-forming reactions
FTIR spectrometer Absorption of infrared energy by molecular bonds, compared against reference spectraIdentification of materials and functional groups, including solids and formulations where a quantitative method is not required
Gas chromatograph Components are separated in a carrier gas stream and detected as they eluteVolatile and semi-volatile mixtures, residual solvents, and purity checks where a separation is required before identification
Liquid chromatograph Components are separated in a liquid mobile phase across a stationary phaseNon-volatile, thermally labile and ionic compounds that would not survive a gas chromatographic method
Mass spectrometer Ions are separated by mass-to-charge ratio and detected, giving high specificityConfirmation and identification where a low detection limit and an unambiguous answer are both required
Atomic absorption spectrometer Ground-state atoms absorb light at element-specific wavelengthsMetal concentrations in water, soils, alloys and biological samples, where one element is determined at a time
TOC analyser Organic carbon is oxidised and the resulting carbon dioxide is measuredWater and wastewater work where organic loading is the reported figure, and where a regulatory limit applies
Particle size analyser Laser diffraction or image analysis derives a size distribution from the samplePowders, suspensions and emulsions, where the distribution rather than a single value is the result

Colorimeters, elemental analysers and the accessories that support these systems are listed under this category as well.

How to choose a analytical instrument

There is rarely a single correct instrument for a duty, but there is always a shortlist that can be justified and a set of answers that eliminates the rest. These are the questions that decide it.

  • The analyte and the matrix together, because the matrix often decides the technique more than the substance does - a clean water sample and a digested solid are different problems with the same target.
  • The detection limit and the reporting threshold, including any regulatory level the result has to be compared against rather than merely detected at.
  • The method or standard the laboratory follows, since an accredited procedure usually names the technique and the acceptance criteria.
  • Throughput: number of samples, preparation time and whether the laboratory works in batches or continuously, which decides whether automation is worth having.
  • The sample preparation route, because extraction, digestion and dilution frequently take longer than the measurement and set the real capacity of the laboratory.
  • Consumables and their supply: columns, lamps, gases, solvents, standards and reference materials, all of which have a running cost and a shelf life.
  • The support environment required: bench space, vacuum, cooling, gas supply, ventilation and power, which is frequently the constraint on which instrument can be installed at all.
  • Data handling: whether results have to be reported in a defined format, held in a laboratory system, or audited against the raw data.
  • Service and calibration support, including access to reference standards and to a service arrangement that can respond within the laboratory downtime tolerance.

Working through the selection in order

  1. State the analyte, the matrix and the concentration range, and confirm what the result is compared against.
  2. Identify the method or standard the laboratory has to follow, since it may fix the technique before anything else is considered.
  3. Establish the detection limit and the acceptance criteria the result has to satisfy.
  4. Choose the technique from those three answers, using the comparison above, rather than from familiarity with one system.
  5. Work out the sample preparation route and check that it can be carried out with the equipment and the staff available.
  6. Size the system for the throughput required, including whether an autosampler or an automated preparation step is justified.
  7. Confirm the installation: gases, vacuum, cooling, ventilation, power and bench space, which frequently decide feasibility.
  8. Decide the consumables, standards and service arrangement that have to be in place for the system to run from day one.

Comparing the technologies

TechnologyBest suited toLimitsTypical question
UV-Vis molecular absorption Quantitative methods built on an absorbing species or a colour-forming reactionNeeds a chromophore, is exposed to matrix interference, and depends on careful cuvette handling and blankingHow much of a known substance is present
FTIR spectroscopy Identifying what a material is, including solids and mixturesWater and some matrices interfere, and interpreting a complex mixture depends on the reference libraries availableWhat is this material
Gas chromatography Volatile and semi-volatile mixtures that have to be separated before they are measuredThe sample has to be volatile and thermally stable, and column and detector selection decide what can be resolvedWhich components are present, and in what proportion
Liquid chromatography Non-volatile, labile and ionic compounds, including large moleculesSolvent consumption and method development time; the mobile phase becomes a running cost and a disposal questionWhat is the composition of a liquid mixture
Atomic absorption Metal concentrations across a wide range of matricesThe classical arrangement determines one element at a time, and some elements need a different atomisation approachHow much of this metal is present
Mass spectrometry Identification and confirmation at low concentration, alone or as a detector for a separation techniqueNeeds vacuum, a controlled environment, consumables and skilled interpretation; it is rarely a stand-alone first purchaseExactly what is present, at very low concentration

Parameters to confirm before ordering

What is left after the technology is chosen is a list of values that only the installation can supply. These are the ones that change the model, the price or the lead time:

  • The analyte or analytes, and the matrix the sample comes in.
  • The concentration range and the detection limit the method requires.
  • The method or standard the laboratory follows, or the acceptance criteria the result is reported against.
  • The sample form and the preparation route, including any digestion, extraction or dilution step.
  • Throughput: samples per day or per batch, and the time available for preparation.
  • The installation available: bench space, power, gases, vacuum, cooling and ventilation.
  • Data requirements: result format, software, storage and whether raw data has to be retained.
  • Consumables and reference standards required with the initial order.
  • Calibration and service expectations, including the interval and the response time the laboratory needs.
  • Whether the laboratory operates under a quality system, and what documentation has to accompany the system.

Figures are quoted, not assumed

Specifications vary by model and application, so no performance figure is stated on this page. Where a parameter has not been documented for a particular model, the product page says so rather than filling the gap with a plausible number. Send the values above and we will return the ones the selected model actually holds.

Where these instruments are used

Frequently asked

Analytical Instruments buying questions

The questions that come up before an order rather than after it. If yours is not here, send it with the requirement and we will answer it in the quotation.

How do I choose between the available techniques?

Start from the analyte, the matrix and the detection limit, and let the method decide. A single element in water and the same element in a digested solid may need different approaches, and a volatile mixture needs a separation before identification while a pure substance may not. The techniques in this category overlap but are not interchangeable, and choosing by requirement is faster than comparing specifications.

What is the difference between a laboratory analyser and an online analyser?

Where and how the sample is handled. A laboratory instrument works on a prepared sample under controlled conditions and is judged on sensitivity and repeatability. An online analyser works on the stream as the process delivers it and is judged on drift and service interval. The same parameter can therefore be measured on both, and the choice depends on whether the answer is needed continuously or on a batch of samples.

Why is the detection limit so important?

Because it decides whether the method can answer the question at all. An instrument that detects a substance but cannot quantify it reliably at the level the result is compared against will produce inconclusive data. It also affects the sample preparation route, since reaching a low limit often requires a concentration step that adds time and error. State the level the result has to be judged against, not just the substance to be detected.

What running costs should be expected?

Consumables dominate: columns, lamps, filters, gases, solvents and reference standards all have finite lives, and some are specific to the model. Add the electricity, cooling and vacuum the system needs, plus the service arrangement. A system with a low purchase price and short-lived proprietary consumables can cost more per sample than a more expensive instrument, so it is worth asking about the consumables list before choosing.

Do these systems need a special laboratory environment?

Most of them do, and the requirement varies by technique. Gas supply, vacuum, cooling water, ventilation and temperature stability all appear, and the bench footprint is rarely the real constraint. A mass spectrometer in particular needs a stable environment and a vacuum system that is maintained. Confirming what the building can provide is worth doing before the instrument is selected.

Can an analytical system be supplied with the method and the standards?

What can be supplied is the instrument and its documentation, and where reference materials or standards are needed they should be named in the enquiry so that they can be quoted together with the system. Method development is normally carried out by the laboratory or by the instrument supplier as a service, and it is worth establishing at the enquiry stage which of those routes applies.

Available now

Published products in Analytical Instruments

Illustrative reference plate for the UV-Vis Spectrophotometer (UVS-1900)

UVS-1900 · Spectrophotometers Reference listing

UV-Vis Spectrophotometer

Double-beam UV-Vis spectrophotometer covering 190 to 1100 nm with a scanning monochromator, for quantitative analysis and wavelength scanning in the laboratory.

Wavelength range
190-1100 nm
Bandwidth
2 nm
Wavelength accuracy
±0.3 nm
Photometric range
-0.3 to 3.0 A

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